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Correlation between Intact Parathyroid Hormone Levels and Subperiosteal Erosion toward Phalanx Manus and Bone Specific Alkaline Phosphatase Level in Pre-dialysis Chronic Kidney Disease Patients

Abstract There is high prevalence of bone disease due to abnormalities of parathyroid hormone (PTH) in chronic kidney disease (CKD). The study aims to determine correlation between iPTH and subperiosteal erosion and b-ALP toward phalanx manus in pre-dialysis CKD patients. The study was used analytical observational research with cross-sectional design. The samples were 60 pre-dialysis CKD patients. iPTH levels was measured using ECLIA method and subperiosteal erosion on phalanx manus was assessed using X-ray. In additions, b-ALP levels were measured using ELISA method. The correlation between iPTH with subperiosteal erosion and b-ALP were analysed using contingency coefficient test. Median of iPTH level was 102.19 pg/ml (12.46-477.30 pg/ml). Subperiosteal erosion was found in 76.7% pre-dialysis CKD patients. Meanwhile, median of b-ALP level was 29.88 ng/ml (12.79-110.38 ng/ml). The contingency coefficient test of iPTH with subperiosteal erosion found r=0.103 and p-value=0.727. Meanwhile, contingency coefficient test of iPTH with b-ALP showed r=0.167 and p-value=0.424.

Thromboembolic involvement and its possible pathogenesis in COVID-19 mortality: lesson from post-mortem reports

Abstract. – The emergence of Coronavirus Disease 19 (COVID-19) as a pandemic has claimed hundreds of thousands of lives worldwide since its initial breakout. With increasing reports from clinical observations and autopsy findings, it became clear that the disease causes acute respiratory distress syndrome (ARDS), as well as a broad spectrum of systemic and multiorgan pathologies, including angiopathy, endothelialitis, and thrombosis. Coagulopathy is associated with the activity of megakaryocytes, which play crucial roles in modulating the platelet homeostasis. Only a few autopsy reports include findings on thrombosis formation and the presence of megakaryocytes. Here we review and summarize the possible involvement and the pathophysiology of the thromboembolic events in COVID-19 patients based on post-mortem reports. We reviewed post-mortem reports from March 2020 to September 2020.

Effect of Cayratia trifolia Ethanol Extract on Bcl-2 expression and Apoptotic Cells in Dmba-induced Breast Cancer of Sprague Dawley Rats

Abstract The study aimed to clarify the effect of the administration of ethanol extract of Cayratia trifolia plants to breast cancer. This study was an experimental study using female animal model of Sprague Dawley rats, consisting of three groups, K0, the normal experimental animals, K1, the experimental animals with breast cancer receiving CMC 0.5%, and KP, experimental animals with breast cancer receiving ethanol extract of Cayratia trifolia in a dose of 300 mg/kgBW at 0.5% CMC. The material to induce breast carcinoma formation was DMBA of 20 mg/kg in corn oil. The extraction of Cayratia trifolia plants used ethanol. The variables were the number of cells expressing Bcl-2 observed with immunohistochemical methods, and the number of cells undergoing apoptosis, which was observed using tunnel assay method. Statistical analysis was performed using ANOVA test. The number of cells expressing Bcl-2 and those undergoing apoptosis in breast cancer tissue between groups of animals receiving and not receiving ethanol extract of Cayratia trifolia showed significant difference (P<0.05). Oral administration of Cayratia trifolia ethanol extract has an effect on the decrease in the number of cells expressing Bcl2 and an increase in the number of cancer cells undergoing apoptosis. 

Preparation and characterization of imprinted zeolite-Y for p-cresol removal in haemodialysis

Rumah Ginjal - In this work, the novel imprinted zeolite (IZ) was synthesized, and its properties and performance in terms of adsorption of p-Cresol, which represent the protein-bounded uremic toxins in aqueous phase under phosphate buffer saline, were studied and compared with the synthesized zeolite-Y (ZeoY-S) and commercial CBV 100 zeolite-Y (ZeoY-C).The ZeoY-S was synthesized from sodium aluminate, NaOH, H2O and SiO2 under aging for 24 h at room temperature and hydrothermal condition for 24 h at 100 °C, with an initial composition of 10SiO2:Al2O3:4Na2O:180H2O.

Determiner of Poor Sleep Quality in Chronic Kidney Disease Patients Links to Elevated Diastolic Blood Pressure, hs-CRP, and Blood-count-based Inflammatory Predictors

Rumah Ginjal - BACKGROUND: Sleep deprivation is strongly associated with cardiovascular disease (CVD) via sympathetic overstimulation and systemic inflammation in general population. However, the significance of poor sleep quality in chronic kidney disease (CKD) is still underexplored. METHODS: This study assessed the sleep quality of 39 with non-dialysis CKD (ND CKD) patients and 25 hemodialysis CKD (HD CKD) patients using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Poor sleeper was defined as individual with PSQI > 5.