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Exploratory correlates of vascular calcification in hemodialysis patients from a resource-limited setting biochemical markers and vascular NF- BSGLT2 expression

Abstract Objective. This study aimed to analyze biochemical determinants of calcification by assessing calcium–phosphate product, magnesium, iPTH, vitamin D3 , NF-κB, and SGLT2 expression as potential markers of vascular injury in chronic kidney disease (CKD). Materials and methods. This cross-sectional study was conducted at Dr. Soetomo General Academic Hospital, involving 30 adult ESRD patients undergoing chronic hemodialysis via radiocephalic arteriovenous fistula. SGLT2 expression was evaluated using immunohistochemistry with a monoclonal antibody against SGLT2 (1:100 dilution, Biocare Medical). Statistical analysis was conducted using the Statistical Package for the Social Sciences (SPSS version 21; IBM Corp., Armonk, NY, USA) and R version 4.5.1. Results. Among 30 CKD patients, vascular calcification was detected in 30% of cases.

Blood Q Creatinine Based on Sex and Age in Healthy Indonesian Geriatrics

ABSTRACT Median blood creatinine (Qcr) is necessary for an accurate evaluation of geriatric renal function. Nonetheless, there is a significant void in existing literature concerning creatinine reference data unique to the elderly. To improve diagnostic precision and clinical decision-making in this susceptible group, this study developed a corresponding Q model for serum creatinine in geriatric patients stratified by age and sex. To determine the Qcr serum and reference range creatinine concentrations, 913 healthy elderly patients (452 males and 461 females) undergoing routine examinations at clinical laboratories were studied. Creatinine concentration reference intervals were divided into 3 age groups, namely: 60-69 years, 70-79 years, and >80 years. The median and percentiles p2.5 (lower reference limit/LRL) and p97.5 (upper reference limit/URL) were determined by the study.

The varied Q creatinine in multi ethnics population and impact of adopting three different estimated glomerular filtration rates based on creatinine in adult populations: a call for performance validation

Background: The determination of kidney function is commonly done by estimating the glomerular filtration rate (eGFR) using serum creatinine levels. Various eGFR formulas, including the recently developed European Kidney Function Consortium (EKFC) and the Chronic Kidney Disease Epidemiology Collaboration(CKD-EPI), have been adopted and are commonly utilized in clinical settings. Nevertheless, the extent of acceptance among these formulations in the multi ethnics populace is still undetermined. Thus, this study aimed to evaluate the performance of these formulations across different glomerular filtration rate categories in the adult population. Methods: The research involved a total of 9,557 individuals (median age of 40 years and 85% being male) who underwent routine medical examinations. Enzymatic or modified Jaffe techniques were employed to measure serum creatinine levels.

Heimioporus sp. (Pelawan mushroom) as source of nutrition and antioxidant

Abstract Edible mushrooms are nutrient-dense, being low in calories yet rich in fiber, protein, vitamins, minerals, and bioactive compounds. The Pelawan mushroom (Heimioporus sp.), an edible variety native to Indonesia, specifically Bangka Belitung, has remained largely unexplored as a bioactive resource. This study aimed to investigate the proximate composition, mineral and vitamin content, and antioxidant potential of Pelawan mushrooms. Samples were collected from Belitung Island, Indonesia, during the rainy season in April 2024. Proximate analysis revealed that Pelawan mushrooms are low in fat but high in protein, fiber, and vitamin A, along with an abundance of essential minerals and vitamins. Extraction using solvents such as n-hexane, ethyl acetate, methanol, and water yielded 3.15 %, 1.26 %, 15.82 %, and 19.11 %, respectively.

Molecular pathophysiology of chronic kidney disease–mineral and bone disorder: Focus on the fibroblast growth factor 23–Klotho axis and bone turnover dynamics

Abstract Chronic kidney disease–mineral and bone disorder (CKD-MBD) is a major complication of chronic kidney disease (CKD), characterized by disruptions in mineral metabolism, abnormal bone turnover and vascular calcification, which collectively increase the risk of fractures and cardiovascular disease. This review examines the molecular mechanisms underlying CKD-MBD, with a particular focus on the fibroblast growth factor 23 (FGF23)–Klotho axis – a key regulator of phosphate balance, vitamin D activation and parathyroid hormone secretion. In CKD, elevated FGF23 levels and reduced Klotho expression contribute to mineral homeostasis disturbances and bone abnormalities. The dysregulation of this pathway plays a central role in CKD-MBD pathophysiology and its associated complications.